Synthesis of Some New 2-substituted Quinazolin-4- One Derivatives and Their Biological Activties
نویسنده
چکیده
A series of mannich bases (3a-3j) were synthesized by the reaction of 4-[2-methyl-4-oxo-4H-quinazolin-3-yl] benzoic acid (2) with formaldehyde and appropriate amines by conventional technique. The procedure afforded various quinazolinone derivatives with 75% yield. Structures were characterized by means of spectral data. All the synthesized compounds were subjected to biological evaluation for antibacterial, antifungal and anti-inflammatory activities.
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